POISE-3 - PeriOperative ISchemic Evaluation-3 Trial

Background: More than 200 million adults undergo major non-cardiac surgery annually. Despite the benefits of surgery, patients suffer major complications. Tranexamic Acid (TXA) may prevent perioperative bleeding in noncardiac surgery but its's safety and efficacy has not been established. Evaluation of a hypertension vs a hypotension avoidance strategy.
Design: Multicentre, international, randomised controlled trial of TXA versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy.
Study intervention: IV bolus or 10 minute infusion of TXA/placebo, with a first dose of 1g given within 20 minutes preceding the anticipated skin incision, and a second 1g dose given at the end of surgery when closing the wound. Patients may also be randomised to a hypertension or hypotension avoidance strategy.
Main inclusion criteria: ≥45 years of age; an overnight hospital stay; non-cardiac surgery

Project Information


Central Adelaide Local Health Network



General surgery

Other (specify below)

End date:

Can this be done remotely?


Senior clinician

Parts of research done:

Literature review, Research proposal, Ethics approval

Positions Available:

New Sites in Australia and New Zealand

Data Collector

Current Funding:

NHMRC for Australian and New Zealand Sites - $1,100 per patient payment

Prospective researchers receive:


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Project owner

Gillian Ormond (for Australian and New Zealand Sites)

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VIC. 3002



0424 730 627


ABN: 77 640 321 295


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